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Pharmaceuticals

The table below sets out patent expiry dates for the active ingredients in significant GlaxoSmithKline products.

   
 
Therapeutic area Product Active ingredient(s) Patent expiry dates for active ingredient(s) in major countries
CNS disorders Seroxat/Paxil paroxetine During or after 2006
  Wellbutrin bupropion Basic compound patents have expired. Formulation patents will expire during or after 2013
  Imigran/Imitrex sumatriptan During or after 2003 (USA 2006/8)
  Naramig/Amerge naratriptan During or after 2010
  Lamictal lamotrigine During or after 2005
  Requip ropinirole During or after 2007
  Zyban bupropion Basic compound patents have expired. Formulation patents will expire during or after 2013
 
Respiratory Flixotide/Flovent fluticasone propionate During or after 2003
  Serevent salmeterol xinafoate During or after 2003 (USA 2008)
  Seretide/Advair fluticasone propionate & salmeterol xinafoate Patents covering the combination will expire during or after 2010
  Flixonase/Flonase fluticasone propionate During or after 2003
 
Anti-bacterials Augmentin co-amoxiclav Basic compound patents have expired, with the exception of the USA (2017), France (2002) and Italy (2007)
  Zinnat/Ceftin cefuroxime axetil Patents to cefuroxime axetil per se have generally expired, although SPCs exist in Europe until 2002. Patents on the amorphous form of cefuroxime axetil will expire during or after 2003
  Fortum/Fortaz ceftazidime Basic compound patents have expired
  Amoxil amoxycillin Basic compound patents have expired
 
Anti-virals Combivir lamivudine + zidovudine Patents on the combination of the two active ingredients will expire during or after 2012
  Epivir lamivudine During or after 2009
  Retrovir zidovudine Basic compound patents have expired. Patents on use in HIV infection will expire during or after 2005
  Ziagen abacavir During or after 2009
  Agenerase amprenavir During or after 2013
  Valtrex valaciclovir During or after 2009
  Zovirax aciclovir Basic compound patents have expired
  Zeffix/Epivir-HBV lamivudine During or after 2009
  Relenza zanamivir During or after 2013
 
Metabolic and Avandia rosiglitazone During or after 2013
gastro-intestinal Zantac ranitidine Basic compound patents have expired
 
Oncology and emesis Zofran ondansetron During or after 2005. During or after 2006 for patents to its use in emesis
   

The patent position on Hepatitis vaccines (Engerix and Havrix) and on Infanrix and LYMErix is highly complex. GlaxoSmithKline is licensed under several US patents pertaining to Engerix, the latest of which expires in 2014. A recently granted US patent pertaining to Havrix expires in 2017. For Infanrix US patents expire during or after 2014. GlaxoSmithKline is licensed under a US patent covering LYMErix that will provide protection until 2014.

GlaxoSmithKline highly values its intellectual property and believes that its worldwide portfolio of patents and trade marks is of particular value.

Intellectual property includes patents, trade marks, registered designs and copyrights.

Patents
GlaxoSmithKline has obtained patents in many countries for the significant products discovered or developed throughout its R&D activities. Patent protection is available in the United States, Europe, Japan and most other significant markets for new active ingredients, as well as for pharmaceutical formulations, manufacturing processes and medical uses.

GlaxoSmithKline continues to have patent protection for one or more forms of most of its key pharmaceutical products in major markets and, in addition, either has obtained patents or anticipates that patent protection will be granted for the new drugs, which are in development. However, the absence of effective patent protection for pharmaceuticals in some developing countries continues to have an adverse effect on pharmaceutical companies, including GlaxoSmithKline.

GlaxoSmithKline is routinely engaged in disputes over its patented products and processes to protect its intellectual property rights (see Note 31 to the Financial statements ‘Legal proceedings’).

Trade marks
All GlaxoSmithKline’s pharmaceuticals products are protected by registered trade marks in major markets, and GlaxoSmithKline pursues a policy of enforcing its trade mark rights vigorously against infringements and other unauthorised uses. These trade marks are used in many countries, although there may be local variations for each. For example, in the United States, the trade mark Paxil is used instead of Seroxat and Advair is used instead of Seretide.

Trade mark protection continues in some countries as long as a trade mark is used and renewed at appropriate times. GlaxoSmithKline’s trade mark with respect to a pharmaceutical product generally assumes increasing importance when the patent for that product expires in a particular country.


Intellectual property - Consumer Healthcare

GlaxoSmithKline’s Consumer Healthcare businesses are brand-oriented and the company considers its trade marks for these products to be of particular value. Consumer brands are protected by trade marks in the majority of the markets where these brands are sold, and GlaxoSmithKline vigorously protects these trade marks from infringement.

   
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