| GlaxoSmithKline has established functional and
reporting relationships for Corporate Environment, Health and Safety
(CEHS) and Employee Health Management (EHM) to encourage the integration
of EHS throughout its business.
R&D Chemical Development
By using more focused and data-driven development, GlaxoSmithKline
can significantly improve efficiency of new processes. This will
make the transfer of processes to manufacturing more streamlined
and give GlaxoSmithKline a competitive advantage. CEHS supports
the Strategic Technologies group within Chemical Development by
providing supporting documentation and tools.
New Product Supply
To promote the use of safer and more environmentally benign processes,
the CEHS Product Stewardship team identifies occupational hazards
and risks and environmental aspects of specific chemicals and processes
so that research & development scientists and engineers can use
this information when selecting materials and processes for producing
active pharmaceutical ingredients.
Engineering, Technology and Capital Management (ETCM)
ETCM ensures that our ethical and legal requirements are incorporated
into new production systems and that capital projects are efficiently
designed with EHS considerations built in. The alliance between
ETCM and CEHS facilitates development of effective and efficient
processes that reduce resource consumption, minimise waste and protect
employees.
Quality
The Quality organisation is a natural partner for CEHS because improved
quality reduces the amount of rejected product, which means less
waste and therefore reduced environmental impact. By sharing information
from their audits of manufacturing operations the EHS and Quality
groups enhance the opportunities to improve the quality of our products
and reduce the environmental impact.
Operational Excellence
The lean sigma approach to operational excellence that eliminates
unnecessary steps and reduces variability is at the heart of the
GlaxoSmithKline culture. Aligning EHS with Operational Excellence
principles helps GlaxoSmithKline reduce waste and protect employees.
Global Manufacturing and Supply
EHS is integral to all manufacturing operations. To ensure that
EHS issues are integrated into manufacturing decisions, the Vice
President of CEHS has a dotted line reporting relationship to the
President of Global Manufacturing and Supply.
Human Resources
To support GlaxoSmithKline employees and ensure EHS is integrated
into employee management, CEHS has a close working relationship
with EHM, part of the Corporate Human Resources organisation.
Sales and Marketing
To integrate EHS into sales and marketing activities, the CEHS Commercial
Support team works to expand EHS programmes, such as driver safety
and office safety, into this area of the business.
Corporate Communications
CEHS integrates EHS messages with corporate messages to build environment,
health and safety into the GlaxoSmithKline culture. We work with
the Corporate Responsibility programme and contribute to policy
statements on environment, health and safety issues.
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GlaxoSmithKline R&D Chemical Development created
a green alternative to metal-mediated ring cyclisations
used to perform transformations. The new alternative
uses photochemically induced single electron transfer.
The photochemical reactor consists of several chambers
housing UV lamps with numerous safety interlocks.
It has been demonstrated on a pilot scale to prepare
an intermediate in multi-kilogram quantities. This
project tied for third place honours in Green Chemistry/Technology
in the 2003 CEO's EHS Excellence
Awards.
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