Rino Rappuoli, Chief Scientist, GSK

Tackling tomorrow’s health challenges today

Our Chief Scientist, Rino Rappuoli, explains how science is helping create the vaccines of tomorrow

Q: Why is it so important that GSK is a science-led organisation?  

A: Everything we do here at GSK is based on science. Each scientific breakthrough over the years has paved the way for the creation of future vaccines for diseases currently beyond our reach.

If we go back in time, the scientist who first imagined the possibility of vaccination was Louis Pasteur, who discovered that infectious agents were causing diseases.

Fast forward to the 1940s and it became possible to grow cells outside of their natural environment. Scientists could now grow viruses in the lab. This resulted in the development of vaccines against measles, mumps, rubella and polio. 

The hard work of scientists didn’t end there. At the end of the 1970s, the next big discovery was conjugate vaccines; bringing antigens and carrier proteins together to help ensure adequate vaccine protection. This made the pneumococcal and meningococcal vaccines possible.

Rino Rappuoli has won a lifetime achivement award

In June 2017, Rino was awarded a Lifetime Achievement Award by the European Patent Office at the European Inventor Awards.

Just a decade later and the discovery of recombinant DNA coupled with progress in genomics paved the way for the development of the first-ever Hepatitis B, Human Papillomavirus (HPV) and Meningitis B vaccines.

Today we’re working on innovation in areas such as adjuvant technologies which help improve the body’s immune response to certain vaccines. These advances have made our malaria and zoster candidate vaccines possible.

Q: How can GSK stay at the leading edge of vaccines science?

A: We’re always trying to anticipate what could happen in the next 10-15 years and where the big advances in the vaccines world will come from. This means staying ahead of the curve particularly when it comes to technology.

Adjuvant technology is one example of being on the leading edge but our most futuristic approach involves synthetic vaccine technology called Self-Amplifying RNA or “SAM”-in short turning viral gene sequences available on the internet into seed stock.

Q: Can GSK conduct leading science like this by itself?

A: The leading technologies I’ve already mentioned are a result of internal scientific work and external partnerships.

What’s critical for us is to be able to both discover new technologies and transform them into vaccines. Our unique value as a company lies in this ability to bridge the gap between scientific breakthroughs and real products making a difference to people’s lives.

To make this difference, we cannot stand still and wait for others to make the discoveries. We need to be working at the leading edge: conducting breakthrough science and developing an understanding of how best to collaborate.

In doing so, you become part of the scientific community, respected by your peers. And this way when someone has a new discovery making a potential new vaccine a possibility, you’re the company they come to. 

Q:How do you ensure the spirit and practice of innovation permeates throughout such a large organisation?

A: What’s most important is the culture we have at GSK and the way we make decisions. Science lies at the heart of both.

Our work is not just about having great ideas; it’s also about supporting them scientifically. We ensure the entire organisation is aware of this and it helps infuse innovation into everything we do.

Q: Science can be hard work- how do you keep employees inspired?

We’re lucky because working in science is exciting in itself. I believe each person has a passion for innovating and finding something new; it’s basic human curiosity.

But as fascinating as science is, it’s also tough. The reality is that the majority of experiments fail so you need to manage your ability to be resilient and bounce back. 

Knowing the ultimate outcome of our work helps. Our jobs are the best of the best because the passion for new scientific discovery is combined with an awareness that what we do improves the lives of millions of people. 

Q: On the personal front, what inspired you to become a scientist? 

A: There were many things, but there is one story which stands out. I was a biology student at the University of Siena and was fortunate enough to listen to a scientific talk given by the professor Albert Sabin about the polio vaccine.

When I saw him a few years later in the mid-70s, he gave a very passionate lecture about this work and how far science had progressed in a relatively short amount of time. By then, I had seen people my age with polio and knew what a terrible disease it was.

Hearing about Sabin’s work and what he achieved really inspired me. To this day that feeling has never left me.