Product development and supply

Programme overview

Product development and supply is a department of scientists and engineers which turns pharmacologically active substances into life-changing medicines.

We progress the development of these medicines from discovery through clinical trials and registration to the factory and beyond.

We also manage Research & Development (R&D) supply chains to ensure that the right experimental medicines or discovery research compounds get to the right place, at the right time, to meet the needs of clinical trial volunteers and scientists respectively.

Science is the bedrock of our success and our scientists are among the world leaders in their fields. If you join the GSK R&D Product Development Future Leaders programme, you'll be part of a network that enables us to register and launch three to five new medicines each year.

What do we look for in a candidate?

To thrive in product development and supply, you will need:

  • Excellent interpersonal, organisational, and communication skills
  • The ability to adapt to change quickly and work under pressure
  • The ability to work in, and influence, diverse multidisciplinary teams
  • The ability to generate and interpret data, and turn it into knowledge
  • A passion for the field of science and engineering that you will work in
  • A desire to apply that science and engineering to the development of new medicines
  • Awareness that there is a patient at the end of everything we do

What will you do

What you will do will be determined by the needs of our product pipeline and the role you are working towards. Because of the highly specialised nature of the science and engineering work that we do, Future Leaders programme roles in product development and supply vary markedly between individual programmes.

Read more about Dee's experience at GSK

"I’d worked hard to gain as much knowledge and experience as I could and I wanted to use this to make the biggest impact on society as possible and to build a more personally rewarding career, which I felt I could do with GSK."

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There are two different paths available

Data Scientist

This exciting new role is part of the Product Development and Supply Future Leaders programme based at a site in the Philadelphia area.

The informatics and data team at GSK are developing a domain of end-to-end product data by integrating and curating data from strategic source systems.  Pharmaceutical development and manufacturing data will be integrated together using an ecosystem of IT infrastructure and big data tools which will enable analytics and new insights from data to be realised.  As the domain continues to grow it will be critical to have experts in data analytics that can unlock business value (new science, improved efficiency, project acceleration) from the data generated throughout the asset lifecycle.

As a data scientist in the informatics and data team at GSK, you will:

  • Lead the definition and delivery (including implementation and change management) of our data science and analytics solutions across a number of R&D departments
  • Provide expert technical input and support on data science and informatics to a number of R&D departments
  • Act as a "voice of the customer" for a number of R&D departments by keeping up-to-date with their challenges and requirements
  • Work closely with partners in manufacturing operations towards the vision of a continuum of data, information and knowledge across the product lifecycle
  • Stay up to date on new developments on the cutting edge of computer science, data science and informatics, bringing in those that have the potential to transform the way we operate
  • Ensure the sustainability of our data science and informatics solutions through the definition and delivery of business processes and guidance material

What do we look for in a candidate?

  • A PhD in mathematics, physics, statistics, computer science, engineering or related field, where programming was used to solve challenging scientific or technical problems.
  • Coursework or research experience relating to the management and/or use of real-world data (e.g. development of algorithms or predictive models).
  • Interdisciplinary research and software development experience using data science languages (MATLAB, Python, R) and/or object-oriented languages (e.g. C++, C#, Java)
  • An understanding of big/complex data (including familiarity with a big data environment such as Hadoop).
  • Ability to interpret large volumes of data in order to derive actionable insights using statistical machine learning and visualisation techniques.
  • Proven ability to map real world problems to algorithmic/computational solutions.
  • Awareness of trends in the pharmaceutical and other industries with regards to data, analytics and knowledge management
  • Willingness to learn about Quality by Design (QbD) principles as articulated in the ICH guidelines Q8 to Q12
  • Awareness of change management principles
  • Awareness of regulatory expectations regarding use of software for GxP business process (i.e. computer system validation).

 

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System based modeller

This challenging new role is part of the Product Development Future Leaders programme based at a site in the Philadelphia area

As a System based modeller at GSK, you will:

  • Provide critical support to GSK efforts to move towards lower cost, more efficient and higher quality processing for small and large molecules. You will identifying and implementing simulation platforms in process development that improve efficiency and increase process understanding.
  • Use systems modelling to speed the development and reduce the cost of process development through minimising ‘wet’ experimentation and equipment builds.
  • Provide leadership to translate modelling and simulation packages generated during development into control strategies and advanced controls that can be implemented to deliver robust processes and products.
  • Apply simulation to Drug Substance and Drug Product processes to identify stable operating regions that deliver quality product.
  • Assist in continuous process equipment and process definition through ‘dry’ experiments that inform the sequencing of unit operations, the determination of process design space, and the impact of perturbations on process performance.
  • Provide leadership in identifying when, where and how to apply advanced controls (e.g. feedback control) for continuous processes.
  • Maintain and apply databases/software required to support simulation (e.g. Aspen properties and equipment databases/libraries)
  • Build expertise and simulation capability across your department in simulation and advanced controls in order to extend the impact of simulation on process development
  • Deliver simulation work packages for drug substance and drug product processes using software such as; AspenPlus or gPROMS.
  • Recommend to project teams and line management experimental programmes required as input to simulation
  • Run lab experiments for operations such as kinetics, extraction and distillation to generate the initial data required for simulation.
  • Perform simulations to guide experimental studies.
  • Use hardware and software skills to assemble and integrate lab scale reactor hardware with control software
  • Use programming skill such as Matlab and C+ to deliver customized simulation modules
  • Develop and maintain current awareness of developing trends in simulation by journal review, presentations, publications and other external networking
  • Contribute to defining strategies and plans to continually improve simulation capability
  • Deliver as needed simulation training and consultation to project teams.
  • Provide input to budget decisions, recommends capital purchases of software and equipment required to support simulations

What do we look for in a candidate?

A PhD in Chemical Engineering with an emphasis in optimisation, chromatographic separations, kinetics/reaction engineering or computational fluid dynamics (CFD). 

  • No more than 2 years of total professional experience
  • Extensive programming experience using languages such as Matlab, Python, R or C
  • Excellent interpersonal, organisational and communication skills.
  • Experience using modelling and simulation software such as Aspen Plus or gProms
  • Experience using real data for developing 1st principle/phenomenological models for multiphase reactors/unit operations preferred
  • Demonstrated ability to independently design and execute work plans.
  • An understanding of thermodynamics and how to predict/model chemical and physical properties of pure compound or mixtures
  • Good understanding of statistical analysis methods on models.
  • Lab and/or manufacturing experience
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As a participants in the Product Development Future Leaders programme, you will be a full-time, permanent employees at GSK and enjoy the same competitive package of salary and benefits as other new starters. In addition, you will undertake three rotations over three years at the start of their career. These rotations will give you technical capability across three separate areas of Product Development and allied disciplines.
You will have regular meetings with your line manager to identify learning and development opportunities, and be given coaching and mentoring to enable you to become a technical leader of the future.
As part of a vibrant, global scientific community, you’ll work in teams that combine a mix of disciplines. We’re at the cutting edge of science and technology, so you’ll never be far from an expert who can help you to learn, grow, and contribute to our business.

You will use the knowledge and experience you gain in this role to become a potential future leader in GSK.
We offer a competitive total compensation package as well as an environment conducive to personal and professional growth. GSK is proud to promote an open culture, encouraging people to be themselves and giving their ideas a chance to flourish.

GSK is an equal opportunity employer.

Rotations

  • 3 rotations

    You’ll spend 16 months in the role for which you have been hired, then your next two rotations will be in two related technical areas of the business.

  • 3 years

    You will choose your second and third rotations during the previous rotations. They will be in the country where you are employed and will meet both your developing aspirations and the needs of the department. You will be encouraged to network and to spend development days in other areas to help you make the very best choice.

Rotations into regulatory affairs, global manufacturing & supply, biopharmaceutical product development, drug design & selection, project management and other technical areas relevant to the department are possible.

What happens next

After completing this three-year program, you will return to the role for which you were hired. The breadth of relevant technical experience, business skills and interpersonal skills you will have acquired, together with the mentoring and networking opportunities you will have experienced, will allow you to excel in your career at GSK.

Locations

USA