Price of world’s first malaria vaccine (RTS,S) for children in endemic countries to be reduced by more than half, to less than $5

• Price reduction is commitment by Bharat Biotech, made possible through partnership with GSK and driven by process improvements, expanded production capacity, cost-effective manufacturing, and minimal profit margins
• Bharat Biotech and GSK make this announcement as part of their pledges to Gavi replenishment process for 2026 - 2030
• Through Gavi support, RTS,S expected to be rolled out in 12 endemic countries in Africa through routine immunisation programmes by end of 2025

Bharat Biotech International Limited (BBIL) and GSK plc (LSE/NYSE: GSK) today announce their commitment to Gavi, the Vaccine Alliance (Gavi), in the continued roll out of the world’s first malaria vaccine, RTS,S. Bharat Biotech will be reducing the price of RTS,S, developed by GSK, PATH and partners, by more than half, to less than $5 progressively by 2028. This price reduction is driven by process improvements, expanded production capacity, cost-effective manufacturing, and minimal profit margins. The announcement forms part of pledges to Gavi for its next replenishment phase (Gavi 6.0, 2026-2030) by both companies.

RTS,S was the first malaria vaccine recommended by the World Health Organization (WHO) in 2021. Since then, GSK has made significant investments to enhance production capacity and efficiency, and to undertake the planned technology transfer to Bharat Biotech. In parallel, Bharat Biotech has invested over $200 million in new, higher-output manufacturing facilities, product development and technology transfers. These enhancements have enabled a phased reduction in the price of the malaria vaccine, starting immediately and fully realised by 2028, when the transfer of production between the two companies is complete.

With Gavi’s support, 12 endemic countries in Africa will have introduced RTS,S through routine immunisation programmes by the end of 2025. This has only been possible through the critical work that GSK has undertaken with Bharat Biotech, PATH, together with the WHO, implementing countries, MedAccess and Gavi, to help deliver access to life-saving malaria prevention for children in endemic countries in Africa.

Dr. Krishna Ella, Executive Chairman of Bharat Biotech International Limited said: "This pledge to Gavi 6.0 is more than a pricing announcement. It's a commitment to global equity, innovation, and collaboration. Through this historic announcement, we aim to change the course of malaria burden for millions of children and families. For us, this is more than a cooperation, it’s a promise. By joining forces with GSK, and working closely with Gavi, and the WHO, we are taking a real step toward closing the gap between vaccine supply and the urgent needs of children at risk of malaria. At Bharat Biotech, we believe technology must deliver on three essentials: safety, affordability, and accessibility. With this collaboration, we are turning this belief into real impact, with the aim of ensuring life-saving vaccines reach the communities that need them most.”

Thomas Breuer, Chief Global Health Officer, GSK, said: "We partnered with Bharat Biotech in 2021 with a common goal: to find a sustainable solution to get ahead of malaria. Today, we announce GSK’s contribution to the long-term price ambition of the world's first malaria vaccine, a key milestone achieved through collaboration with Bharat Biotech and partners from Gavi, PATH and the WHO. This demonstrates our commitment to changing the trajectory of infectious diseases like malaria, making a difference in the lives of children and families across Africa. The GSK team has worked hand in hand with Bharat Biotech to transfer the vaccine manufacturing technology, while simultaneously implementing crucial improvements in manufacturing efficiencies, resulting in today’s pledge to the Gavi replenishment.”

The body of data generated from studies of the malaria vaccine developed by GSK, PATH and partners spans multiple years in malaria endemic countries, multiple seasons and in high transmission settings. In a recent evaluation of impact by the WHO of the Malaria Vaccine Implementation Programme (MVIP) in Ghana, Kenya and Malawi, where over 2 million children received the RTS,S vaccine between 2019 and 2023, the WHO reported a 13% reduction in all-cause mortality and a 22% reduction in hospitalisations of severe malaria among children age-eligible for vaccination during this period¹. When administered seasonally in regions with high malaria transmission, alongside seasonal malaria chemoprevention, the two malaria vaccines recommended by the WHO, have been shown to prevent approximately 75% of malaria episodes².

Malaria vaccines are part of the malaria “tool box” alongside other interventions such as seasonal chemoprevention, malaria treatments, Indoor Residual Spraying (IRS) and bed nets. While no single intervention recommended by the WHO for malaria control is sufficiently efficacious to serve as a standalone intervention, malaria vaccines are one of the high-impact malaria interventions. Building on this foundation, research has begun at GSK to develop a new vaccine designed to further improve protection for children in endemic countries against the most severe form of malaria. By targeting a different stage of the life-cycle of the malaria parasite, this work aims to evolve and expand the global malaria “tool box,” in support of elimination efforts.

Dr Sania Nishtar, CEO of Gavi, the Vaccine Alliance said: “We are grateful to GSK and Bharat Biotech for their innovation and commitment to protecting millions of children and communities from malaria. With the support of our partners, Gavi has helped 20 countries in Africa – nations that together shoulder over 70% of the global malaria burden – protect their children, communities and health systems. Our ambition is to protect at least 50 million more children across Africa by the end of 2030, and this collaboration between GSK and Bharat Biotech helps put this goal firmly within reach.”

Dr Kwaku Poku Asante, Director of the Kintampo Health Research Centre, said: “As an epidemiologist working in malaria vaccine development and delivery, I have seen the impact malaria vaccines are already having on children in high-burden regions of Africa. As a result of the collaboration between the research community in implementing endemic countries, industry, NGOs and multilateral organisations, the world’s first malaria vaccine is helping to reduce all-cause mortality and hospitalisations of severe malaria among children. Today’s announcement of a long-term price reduction by Bharat Biotech, with GSK’s contribution, marks a pivotal moment for the malaria community. Any lower cost vaccine means children in the most affected communities in endemic countries can be protected. Sustained affordability is essential to ensuring that the progress we’ve made in malaria control is not only maintained, but accelerated.”

About Bharat Biotech International Limited (BBIL)

BBIL is a biotechnology company headquartered in Genome Valley, Hyderabad, India, focused on providing affordable vaccines and bio-therapeutics for combating infectious diseases. BBIL has more than 145 global patents, a product portfolio of more than 19 vaccines and four biotherapeutics, registrations in more than 125 countries, and the World Health Organization (WHO) Pre-qualifications. BBIL has delivered more than 9 billion doses of vaccines worldwide, and has developed vaccines for influenza H1N1, Rotavirus, Japanese Encephalitis, Rabies, Cholera Chikungunya, Zika, and the world’s first tetanus-toxoid conjugated vaccine for Typhoid. To address the COVID-19 pandemic, the company developed its indigenous COVID-19 vaccines.

To learn more about Bharat Biotech, visit www.bharatbiotech.com.

About GSK

GSK is a global biopharma company with a purpose to unite science, technology, and talent to get ahead of disease together. Find out more at gsk.com.

Cautionary statement regarding forward-looking statements

GSK cautions investors that any forward-looking statements or projections made by GSK, including those made in this announcement, are subject to risks and uncertainties that may cause actual results to differ materially from those projected. Such factors include, but are not limited to, those described in the “Risk Factors” section in GSK’s Annual Report on Form 20-F for 2024, and GSK’s Q1 Results for 2025.

References

1. World Health Organization, World Malaria Report 2024 https://www.who.int/teams/global-malaria-programme/reports/world-malaria-report-2024 (Accessed June 2025)
2. World Health Organization, Malaria vaccines (RTS,S and R21) (Accessed June 2025)